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apalutamide will lower the level or outcome of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. Coadministration of apalutamide, a solid CYP3A4 inducer, with medication which are CYP3A4 substrates may result in lower publicity to those remedies.For anyone who is concerned about withdrawal signs or di